Reduced growth hormone secretion after cranial irradiation contributes to neurocognitive dysfunction
نویسندگان
چکیده
منابع مشابه
Growth and Growth Hormone Secretion Following Cranial and Craniospinal Irradiation in Children with Malignant Disease
grow. The Bristol paediatric oncology and paediatric endocrinology services have collaborated to investigate the effects of chemotherapy and craniospinal irradiation on the longitudinal growth of survivors. Figure 1 shows the longitudinal height-attained growth chart of a child who grew poorly following treatment for a medulloblastoma. Our experience, and that of others, is that children treate...
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Background: When the hypothalamic-pituitary axis (HPA) is included in the treatment field in children and adults, a variety of neuroendocrine disturbances are more common especially in children than has been appreciated in the past. This study was carried out to evaluate growth hormone secretion and the hypothalamic-pituitary-thyroid axis function in children after cranial radiotherapy. Subject...
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Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance ...
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Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance ...
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This study analyses the growth and the growth hormone secretion of children given various conditioning protocols before bone marrow transplantation (BMT). Twenty nine children (14 boys, 15 girls) given BMT were classified according to their conditioning protocol: total body irradiation (TBI) given as a single exposure of 10 Grays (Gy, group I, 11 cases), or 8 Gy (group II, four cases), 12 Gy gi...
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ژورنال
عنوان ژورنال: Growth Hormone & IGF Research
سال: 2012
ISSN: 1096-6374
DOI: 10.1016/j.ghir.2011.12.007